Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats
Losing muscle while losing fat means the metabolism slows more than it should, making weight maintenance harder after the medication is discontinued
Viennois and colleagues (Cell Mol Gastroenterol Hepatol, 2016, PMID 27458604) reported that the effect was lost in PepT1-knockout mice, making the transporter the gating step
Specifically, the contribution of emerging global profiling studies based on proteomics, transcriptomics and metabolomics to these insights will be highlighted
In vivo protein targets for increased quinoprotein adduct formation in aged substantia nigra
But to keep our readers on topic, I will discuss the how-to from a post-failure perspective