Heavy metals (including lead, cadmium, mercury, and the metalloid arsenic) are persistent in the environment and have documented potential for serious health consequences
In addition to JPH-203, other drugs currently in preclinical and clinical trials targeting LAT1 include IPA-131, QBS-10072S, TLX101-CDx, 124I-ACD-101, 211At-TLX-102, OKY-034, [18F] NKO-028 (Table 1)
Cell 173 , 7489.e20 (2018)
Zhang HW, Ding J, Jin JL, et al
Consistent with the in vivo experiments, the levels of cytochrome c in HG + PA groups were increased in the cytoplasm and decreased in the mitochondria compared to the control groups
They are a relatively new type of diabetes drug and have only been used to treat diabetes since the mid-2000s