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doi: 10.1016/S0140-6736(21)00845-X

NRF1 (NFE2L1), a proteasome activity sensor localized to the endoplasmic reticulum, is normally degraded by ERAD

30 Impaired mitophagy contributes to cardiac dysfunction and fibrosis in obesity, primary cardiomyopathies, and HIV-associated cardiomyopathy (HIVAC)

This regional specificity, combined with the preservation of lean tissue, suggests favorable body composition changes even when total weight loss is moderate