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Two Phase 3 Trials of Gantenerumab in Early Alzheimers Disease

These perhaps most significant findings regarding DSIP have been confirmed in other studies, which have shown that DSIP improves sleep structure and efficiency, and reduces sleep latency in chronic insomnia compared to placebo

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Only about 17% of patients under 10 years of age are found to have neuropsychiatric symptoms at presentation, whereas in patients presenting after 18 years of age, 74% experience neurologic manifestations.2,20 It is usually after 10 years of age that patients may manifest evidence of involvement of the other organ systems such as renal, hematologic, and endocrine (Figure 252)

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