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As a result, only the novel catechol siderophore-conjugated cephalosporin antibiotic, cefiderocol has progressed beyond the first phase of human safety trials, owing to a unique combination of structural features derived from cefepime and ceftazidime that overcomes that stability problems associated with earlier iterations (Page et al., 2010)

complementarity determining regions (CDRs - CDR1, CDR2, CDR3) compared to 6 in classical antibodies, but still bind with affinities in nano/pico molar concentrations (177)

doi:10.1089/107555302317371451

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Studies have investigated the anti-urease efficacy of molecules containing free thiols (Milo et al., 2021)