Some had been accused of taking the easy way out. I think that there is kind of a stigma that its a cop-out, one participant said, that youre just taking the easy way out rather than doing it with diet and exercise like you should. Reflecting on the findings, de Vere Hunt shares, I expected perceived stigma to be present for people taking GLP-1 RA medications, but I was surprised by how strongly it still emerged in interviews. A particularly important finding, she added, was that many participants felt society viewed GLP-1 use differently depending on the reason: diabetes treatment was seen as legitimate, while obesity treatment was often framed as cheating. Biologically this doesnt make much sense, de Vere Hunt said, as obesity is also a chronic disease involving dysregulated hormonal and metabolic pathways with serious long-term health implications. Yet eligibility criteria, she said, can reinforce the misconception that people do not need medical support to treat obesity alone
Additionally, CD147-targeting therapies, including anti-CD147 antibodies, modulate MCT1/4 surface expression, although off-target effects remain a concern (184)
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Critics immediately pointed out the troubling message, arguing that a worldclass athlete was not the target demographic for these medications, and that celebrity endorsements like this risk normalizing overuse while pushing those who actually need the drugs further toward the margins
