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Furthermore, TMAO exacerbates VC through dose-dependent vascular smooth muscle cell calcification and activation of the NLRP3 inflammasome and NF-B signaling (Zhang et al., 2020), thereby further promoting thrombosis (Figure 6)

Each chamber is separated by valves that ensure blood flows in a single direction

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doi: 10.1039/d1fo02608a, PMID: [DOI] [PubMed] [Google Scholar] 41.Lv B, Wu Y, Lian J, Yu N, An T, Wang T, et al