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Addition to an SGLT2i medication occurred for 12.1% of patients

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Discontinuation is associated with older age (65+ years), poor weight response, and moderate or severe GI side effects [70]

Retatrutide achieved approximately 17.5% weight loss at 24 weeks compared to semaglutide approximately 10-11% at the same time point

Zepbound is also indicated for people with moderate to severe obstructive sleep apnea and obesity

GIP Receptor Distribution GIP receptors are found in your pancreas (beta cells and alpha cells), fat tissue (adipocytes), bone, brain (limited distribution compared to GLP-1), stomach, and intestines