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Sample preparation is based on effective extraction of the analytes from the blood spot without any further sample preparation steps required

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Martinez-Gonzalez, I., Steer, C

Biology is always listening

So the practical takeaway is not oral is better or SC is better. It is: pick one route, follow the documented per-dose figure for the vial you have, and keep the route constant so that whatever you observe is not confounded by a mid-stream route change

Route-specific and Other Contraindications: Bacteriostatic Water must not be used for large-volume intravenous fluid replacement or hydration therapy