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Retatrutide is not licensed by the MHRA in the UK as of 2025 and cannot be legally prescribed outside an approved clinical trial or a formal MHRA access scheme

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People taking Saxenda may want to switch to Wegovy because there are fewer injections needed (once weekly versus once daily), and Wegovy may be more effective at aiding weight loss

This dual agonist action is a big part of why this comparison tends to favour Mounjaro on blood sugar and weight loss

For weight management or more pronounced glucose control, the dose may be gradually increased to 1.0 mg or higher over several weeks

More LDL receptors on the cell surface means more circulating LDL-C is cleared from blood