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The Bottom Line A new biweekly GLP-1 injection called bofanglutide showed results comparable to weekly semaglutide in a Phase 2b trial but the drug has no FDA approval, was tested only in Chinese patients, and is years away from U.S

For individuals who cannot tolerate weight loss injections after cholecystectomy, or for whom they are unsuitable, several evidence-based alternatives exist within NHS pathways

Younger users with less accumulated damage may notice changes sooner, while older users with more significant collagen loss may need the full 12+ weeks before results become clearly visible