This methylation affects the region containing CTCF binding sites
Early studies on the molecular mechanisms of PD entailed a combination of fast cyclic voltammetry (FSCV), microdialysis, high performance liquid chromatography electrochemical detection (HPLC-ECD), and functional imaging (PET) [367, 368]
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Striatal dopamine levels reached 7.14 1.19 ng/mg tissue, alongside significant increases in metabolites such as homovanillic acid (3.59 0.51 ng/mg compared to 1.93 0.43 ng/mg in controls) and 3,4-dihydroxyphenylacetic acid (13.43 1.62 ng/mg compared to 8.97 1.49 ng/mg in controls)