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The GLP-1 receptor is a class B G protein-coupled receptor (GPCR) found in: Pancreatic beta cells Hypothalamic and brainstem nuclei Gastrointestinal tract Heart, kidney, and elsewhere Upon activation, it triggers multiple intracellular pathways: cAMP/PKA: enhances insulin secretion PI3K/Akt: promotes cell survival and beta cell function MAPK/ERK: involved in cell proliferation, differentiation, and potentially neuroprotective effects These pathways interact in complex ways depending on cell type, receptor density, and ligand properties

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Surgery 120:360366 Prinz M, Jung S, Priller J (2019) Microglia biology: one century of evolving concepts

Fifty years in, and researchers are still pulling new findings out of a compound made from three amino acids and a copper ion

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