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GLP-1 RA Head-to-Head Trials In summary, these head-to-head clinical trials between GLP-1RA and DPP-4 inhibitors showed that the difference between the drugs lies in the ability of the GLP-1RA to consistently improve glycemic control and decrease weight ( Switch Trials A small number of clinical trials have evaluated switching patients from a DPP-4 inhibitor (sitagliptin) to a GLP-1RA

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