Orphenadrine (100 mg twice daily), an anticholinergic, significantly reduced cramp frequency, severity, and duration, as supported by a placebo-controlled trial with minimal side effects
Also, the number of participants was very small
doi: 10.3389/fmicb.2025.1651965 Received 22 June 2025 Accepted 25 September 2025 Published 17 October 2025 Volume 16 - 2025 Edited by Joo Miguel Rocha, Laboratory of Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Portugal Reviewed by Kimon Andreas Karatzas, University of Reading, United Kingdom Abdul Bari Shah, Al-Farabi Kazakh National University, Kazakhstan Updates Copyright 2025 Kezer, Paramithiotis, Khwaldia, Harahap, agalj, imat, Smaoui, Elfalleh, Ozogul and Esatbeyoglu
Required Actions: Eli Lilly must take immediate action to address any violations, including ceasing and desisting promotional communications that are misleading
There are no studies or data that show that micro-dosing works
With so many options out there, how do you even begin to choose the right path
