UK guidelines recommend monitoring clinical response and full blood count (typically at around 2 months) to ensure treatment adequacy, rather than routinely rechecking B12 levels after replacement has started
May cause drowsiness, do not drive or operate heavy machinery until you know how it affects you
Proponents argue this maintains more stable tissue levels, though others find once-daily dosing equally effective with better compliance
The concentration is similar, typically 2 mg per mL
Common effects of sudden discontinuation include: Return of appetite : The appetite-suppressing effects diminish, often leading to increased hunger and food cravings Blood glucose elevation : For those with type 2 diabetes, blood sugar levels typically rise as the glucose-lowering effects wear off Weight regain : Many patients experience weight increase, sometimes rapidly, as metabolic changes reverse Gastrointestinal changes : The slowed digestion that Ozempic provided normalises, which some patients notice as altered bowel habits It is important to understand that stopping Ozempic suddenly does not typically cause dangerous withdrawal symptoms in the traditional sense
doi: 10.1038/nrc3106
