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Cytosolic synthesis of GSH takes place in two ATP-dependent reactions catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthase (GS)

In the Alpha PMI method, poses are generated by aligning ligand conformations principal moments of inertia to a randomly generated subset of alpha spheres in the receptor site

Through these integrated pathways, glutathione serves as a key regulator of brain cellular metabolism, supporting long-term neuronal function

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