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In contrast to the CV outcomes trials with GLP-1RAs, those with DPP-4 inhibitors demonstrated consistent non-inferiority in both the primary composite outcome and individual components compared to placebo, and even showed some unexpected increases in risk of hospitalization for HF, acute pancreatitis, and hypoglycemia [31,32,33,34]
Older users may need longer protocols to achieve comparable results
the obese mice also demonstrate lower GPx activity, which catalyzes the reduction of the oxidized form of glutathione to GSH
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