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The factors favoring escalation to 12mg include: weight loss plateau before reaching goal, BMI above 40 with significant weight to lose, and good tolerability with minimal side effects during escalation

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Trial protocols may test different dose levels and escalation schedules, but those details are not prescribing instructions

[17] [18] Supply constraints have affected NHS availability

Tirzepatide, a dual GIP and GLP-1 receptor agonist, follows a similar pattern but uses different dose increments: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg