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Critically, neither the original 2021 meta-analysis nor the 2025 JAHA study found a significant association between GLP-1 medications and pulmonary embolism

& Hirota, J

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However, if new leg pain, swelling, or skin changes accompany the change in appearance, see a vein doctor for an ultrasound evaluation to confirm what is actually happening

If you want to explore compounded GLP-1 options with personalized titration guidance, you can check your eligibility here

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