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For example, estrogen signaling has been shown to enhance the anorexigenic effects of GLP-1 RAs by modulating central pathways involved in food reward, which could account for the more pronounced weight loss observed in premenopausal women [49, 50]

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Severe or persistent nausea may impair nutritional intake and quality of life, warranting intervention

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Smaller retrospective studies those that look back in time suggest that there are benefits to using GLP-1 medications with type 1 diabetes