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This is evidenced by the negligible affinity of amylin or pramlintide for the isolated CTR ECD 19,20 , and by loss of affinity and/or potency of P32Y substituted CT peptides at the CTR 18,20

Next, we determined whether sg CBS could affect the TSS pathway activity and GSH generation at different cystine levels

This pathway has been studied in several in vitro models and is under investigation as a potential therapeutic target in several cancers, including breast, ovarian, liver, and prostate 15,16,17,23

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