Even though the oral dose is higher, only a tiny fraction actually enters the bloodstream
This explains why many patients report hair loss appearing several months after starting their GLP-1 medications, not immediately
In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]
However, we emphasize that GLP-1 medications are most effective when integrated into a holistic treatment plan
In addition to helping with insulin resistance, these medications can benefit those with PCOS in other ways: by promoting weight loss, regulating menstrual cycles, reducing chronic inflammation, and lowering the risk of cardiovascular disease and non-alcoholic fatty liver disease, conditions that can be associated with PCOS
When you're in pain all the time, a lot of times you're not a very nice person
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