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2020;45((Suppl
ROS are mainly derived from the mitochondria where they are regularly produced as a natural byproduct of metabolism [55]
Among the most promising therapeutic approaches, much research interest has been devoted to catalytic metal-based anticancer agents that could convert natural biomolecules into (cytotoxic) products or products that ultimately lead to cell death
The protein concentration of serum IgG fractions was estimated with Pierce Coomassie Plus (Bradford) Assay Kit (ThermoFisher Scientific, St
In addition, stimulated AngII produces ROS which in turn causes mitochondrial dysfunction, mitochondrial DNA lesions, heart failure, fibrosis, and cardiac hypertrophy (Dai et al
Trials should co-primary (1) mechanistic change (e.g., Prx cycling, 2-OH-E, LIP) and (2) clinical improvement (function, organ scores), preventing the common trap of ROS lowering without benefit (Guideline 2022)
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