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ABCA1 gene expression remained unchanged regardless of SREBP-2 silencing

Neutrophil-derived proteolytic enzymes (i.e., myeloperoxidase and elastase) may also be involved in the initiation of AT inflammation (132)

The RNA-seq and qRT-PCR results for both up- and downregulated genes showed a strong positive association (r = 0.854, p = 0.007

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It is expressed on regulatory T cells, endothelial cells, oligodendrocyte lineage cells, and select neurons and can induce pro-survival signaling by procuring TRAF2 [28] and activating the PI3K/NF-B pathway [75,76,77,78], thereby protecting against excitotoxic and ischemic damage [75, 76] (Fig