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It is ubiquitously present in mammalian cells and plays a central role in redox balance, cellular detoxification processes, and maintenance of intracellular thiol status

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For example, in Section E we showed that moderate oxidative stress causes blood GSH and blood cysteine to rise, but severe oxidative stress causes blood GSH and blood cysteine to fall

In contrast to mitochondrial and microsomal GSTs, cytosolic GSTs are present in the cytoplasm and are soluble [44]

Inflammation increases oxidative processes and some autoimmune diseases are associated with an increase in oxidative stress and a decrease in glutathione levels

Wang, C., Zhang, Y