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Rapid endothelial restoration and activation of the major collaterals (in addition, there are abundant anastomoses between individual vessels on both surfaces of the large intestine (Vukojevic et al., 2018

Daniela Hurtado, an endocrinologist at the Mayo Clinic

Tricyclic antidepressants (amitriptyline, nortriptyline) inhibit both serotonin and norepinephrine reuptake while also blocking histamine, acetylcholine, and alpha-adrenergic receptors