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This is the phase 2 trial of retatrutide in individuals with obesity (without type 2 diabetes) in which much of the discussion of this review is focused

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The trial included 60 adult participants (mean age approximately 49) who had clinical follow-up with labs every 2 months for up to 2 years, with some withdrawing early due to spontaneous remission, indication for definitive therapy (e.g., thyroidectomy or radioiodine), or an intolerance to the treatment