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Genitourinary effects primarily relate to Jardiance and include: Genital fungal infections (vulvovaginal candidiasis in women, balanitis in men) Urinary tract infections Increased urination frequency (due to glycosuria) Symptoms of volume depletion (dizziness, particularly on standing) Maintaining good genital hygiene and adequate hydration helps minimise these risks

Severe nausea, defined as nausea that interfered with daily activities or required medical intervention, occurred in approximately 2.4% of semaglutide-treated participants in STEP-1 [1]

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The medication also contributes to lower blood pressure and reduces inflammatory markers and oxidative stress

The primer sequences can be found in Supplementary Table 1