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In both studies, AUC and C max reductions were similar after the first treatment dose and at the steady-state dose through titration

One protective mechanism of GLP-1 receptor (GLP1R) agonists offers protection by boosting insulin sensitivity, which subsequently enhances endothelial function

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101 In a pilot study in adult PWS and obese control patients, a single dose of 10 g of the GLP-1 receptor agonist exenatide increased satiety independently of the measured appetite hormones, lowered glucose before and during a control meal, and increased the insulin secretion rate in both groups

doi: 10.1038/nature22378