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P values represent within-group comparisons between baseline and 12 weeks using paired t tests or Wilcoxon signed-rank tests

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Mirroring data from sAC / mice, depletion of sAC in human caSMCs through a siRNA also abrogated cAMP responses to GLP-1(2836) (Figure 2I), providing further evidence of a nonreceptor, sAC-dependent mechanism