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This is not FDA-approved

Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality and renal outcomes in patients with diabetes and albuminuria: a systematic review and meta-analysis

The combination can produce weight losses of 150, 200 pounds numbers that were really unachievable before. Theres also one practical argument for surgery that doesnt get much attention: permanence

PMID: 38806481

Although these drugs demonstrated effectiveness in improving blood sugar control and promoting weight loss, lawsuits now allege that GLP-1 receptor agonists may also be associated with severe gastrointestinal injuries, optic nerve complications, and other serious adverse health effects

Some explanations for these strong effects come from mechanistic studies investigating the proportions of the respective GLP-1 and GIP receptor agonistic properties