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The VEGF/VEGFR2 pathways are known to be highly active in roughly half of all human cancers, ranging from ovarian cancer to melanoma

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Recent studies have shown that glutamine-derived -KG regulates the differentiation of CD4(+) T cells into Th1-type effector T cells or Treg cells via DNA methylation and lipid homeostasis 135,136

MnSOD is essential for life, as the knockout (KO) of MnSOD is lethal to neonatal mice (Li et al., 1995

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