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It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs)

Safety, Side Effects, and What to Expect During GLP-1 Treatment Common early side effects of GLP-1 therapy include mild nausea, reduced appetite, and occasional gastrointestinal changesmost resolve within 1-2 weeks as your body adjusts

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Once you stop increasing the dose and stabilize, some patients find their GI symptoms plateau at a tolerable level, while others discover that the cumulative effect of 12 months of medication has created a persistent change in bowel consistency