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The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Sorkheh K., Shiran B., Khodambashi M., Rouhi V., Mosavei S., Sofo A

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