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However, the degree to which they affect brain functions related to appetite control and sugar homeostasis has remained elusive

Clinical trial data show that gastrointestinal adverse effectsincluding nausea, vomiting, diarrhea, and abdominal discomfortoccur in 20-50% of patients initiating GLP-1 therapy, with rates varying by specific agent and dose

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A single CJC-1295 DAC injection raises IGF-1 by 1.5-3 fold within 2-4 days, with levels remaining elevated for 9-11 days (PMID: 16352683)

While that may not seem like many patients, keep in mind osteoarthritis is a degenerative disease and retatrutide is not a pain medication